The first match after the international break sees the biggest game of the season, with the Manchester derby pitting Mourinho and Guardiola against each other for the first time in English football. The 3pm kick offs follow with Arsenal hosting Southampton at the Emirates and Bournemouth hosting West Brom at the Vitality Stadium.
Manchester United vs Manchester City – Saturday 10th September 2016 – 12:30 - Sky Sports 1
Manchester United welcome Manchester City to Old Trafford this Saturday, in one of the biggest fixtures of the season that see's the return of Mourinho against Guardiola.
Jose Mourinho will be delighted with his side's start to the season, with the maximum points from his first three games and the knowledge that they can still improve.
They come into this match on the back of a 1-0 win against Hull, with a late goal from Marcus Rashford ensuring all three points went back to Manchester.
It was a good performance away from home, with United eventually breaking through a stubborn Hull defence.
Mike Phelan's side put in an incredible rearguard effort, they showed exactly why they have been so hard to beat this season.
Much More To Come
The inspired substitution of Marcus Rashford gave United a cutting edge, with pace on the flanks and the pinpoint ball from Rooney ensuring he made his mark.
United and England captain Rooney has been pivotal for United, supplying the opening goal in both the Southampton and Hull matches.
Zlatan Ibrahimovic has been an excellent addition as well, he is a proven goal scorer and has four goals in his last four matches.
Huge Match For United
This is a match that sees Manchester City make the short trip to the Theatre of Dreams, with both sides looking to maintain their unbeaten records.
Mourinho will be desperate to lay down a marker for this season, by beating City they will have gone up another level in opposition.
United will be wary of City's attacking threat coming into this match, although the suspension of Sergio Aguero is a massive boost to Manchester United.
After two games United are in third place in the Premier League, with a goal difference of +5, they have only conceded one goal this season.
Manchester City have also conceded in every match this season, they have scored 9 goals in three matches and only Sunderland have pushed them all the way.
United will be looking to continue their record against Manchester City. In 147 matches, they have won 58, drawn 46 and lost 43.
Manchester United are 5/4 with Zlatan Ibrahimovic to open the scoring at 4/1.
Manchester City have also enjoyed an excellent and unbeaten start to the season, they find themselves top of the Premier League going into this match.
Their last fixture prior to the international break was a 3-1 win against West Ham, with goals from Raheem Sterling (2) and Fernandinho enough to preserve their unbeaten start.
Guardiola's men have been clinical in front of goal, they have scored 9 goals this season, two more than second-placed Chelsea and three more than United.
They have conceded more than their city rivals as well, leaking a goal in every game and they will not be able to afford United too many chances.
Early Signs Are Good
The early signs under Pep have been very encouraging, they have improved with every game and in their last game enjoyed the lion's share of possession and shots on target.
Raheem Sterling's evolution under Pep has also continued, with the much maligned forward registering two vital goals against the Hammers.
John Stones has grown with every minute played, he has also paid tribute to the former Bayern and Barcelona coach for helping him develop.
United Present Huge Challenge
Manchester City face the biggest challenge of their season, with Mourinho and United proving to be a formidable pairing.
United come into the fixture unbeaten and have only conceded one goal, without the suspended Aguero key players will have to step up.
These two sides drew 0-0 at Old Trafford last season, with the managerial changes this season both sides will be desperate to gain an early psychological advantage.
Manchester City are 11/5 with Kelechi Iheanacho at 13/2 to score first.
Arsenal vs Southampton – Saturday 10th September 2016 – 15:00
Arsenal welcome Southampton to the Emirates this Saturday, in a match that pits two Frenchman in Wenger and Puel against each other.
Arsene Wenger will be delighted with his side's last result, with a battling 3-1 win against Watford ensuring they took their first three points of the season.
It has been a disappointing start to the season for Arsenal, with a 4-3 defeat at home to Liverpool followed by a goalless draw against Leicester.
The Watford result will have given Wenger and his men cause for optimism, this match against Southampton will be a good test for them.
Much More To Come
Arsenal will be looking to push on having won their first match, along with the signings of Mustafi and Perez there will be a feel-good factor at the club.
They have been inconsistent in their results but Wenger will be looking for the club to secure back to back wins, to keep up with the Manchester clubs and Chelsea.
They find themselves in 8th position, with a goal difference of +1 and will need to win this game to put themselves back in contention.
Huge Match For Arsenal
This is a match that sees Southampton make the trip to the Emirates, with both sides looking to avoid a second loss in four games.
Arsenal will be looking to improve their recent record against Southampton, which has seen them fail to win their last three matches, with two of them resulting in heavy defeats.
Southampton have endured a poor start to the season under their new manager, with the Saints looking a shadow of the side that they were under Ronald Koeman.
The Gunners defence has leaked 5 goals in three games, something that Arsenal will need to address if they are to have any realistic chance to win the league.
The new recruits in Mustafi and Perez will have got the fans back on Wenger's side, with the german international an excellent recruit, albeit a touch expensive.
Arsenal will be looking to continue their overall record against Southampton. In 79 matches, they have won 38, drawn 22 and lost 19.
Arsenal are 8/13 with Olivier Giroud the favourite to score first at 7/2.
Southampton have struggled under new coach Claude Puel this season, with the Frenchman failing to win any of his opening three matches.
Their last fixture prior to the international break was a 1-1 draw against Sunderland, with a late Jay Rodriguez goal enough to rescue a point for the Saints.
Puel's men have struggled in front of goal, scoring only twice in their opening three games and they have conceded four goals.
With problems at both ends of the pitch, it does spell trouble for the Saint's newest managerial incumbent.
Boufal Signing Key
The early signs under Puel have been less than encouraging, they have remained fairly solid despite only registering two points and will be targeting improvement up front.
With Jay Rodriguez netting a much-needed goal, after an extended period out injured they will be relying heavily on new signing Sofaine Boufal.
Former Lille winger Boufal, was a club record signing at £16 million and he will be expected to provide the firepower needed for the Saints.
Arsenal Represent Huge Challenge
Southampton face another big challenge in the form of Arsenal this weekend, having already faced a strong United side they will be looking to put in a much-improved performance.
Arsenal come into the fixture having struggled for form and consistency themselves, they will feel they have turned the corner after their 3-1 win against Watford.
These two sides drew 0-0 at the Emirates last season, with the managerial change at Southampton this season giving Arsenal a distinct advantage.
Southampton are 17/4 with Shane Long at 17/2 to open the scoring
Bournemouth vs West Brom – Saturday 10th September 2016 – 15:00
Bournemouth welcome West Brom to the Vitality Stadium this Saturday, with Bournemouth looking to register their first win of the new season.
Eddie Howe will be happy with his side's last result, with a battling 1-1 draw away against Crystal Palace ensuring they took their first point of the season.
It has been a disappointing start to the season for Bournemouth, with two defeats and a draw from their opening three matches.
The Palace result will have given Howe and his men cause for optimism, this match against West Brom will be an ideal opportunity to get their first home win of the season.
Much More To Come
Bournemouth will be looking to push on having registered their first point, along with the key signing of Wilshere there will be a feel-good factor at the club.
They have been inconsistent at the back in their last two results against West Ham and Crystal Palace, it has so far cost them four points.
They find themselves in 19th position, with a goal difference of -3 and they will need to win this game to put themselves back in contention.
Huge Match For Howe
Bournemouth will be looking to maintain their recent record against West Brom, with both sides enjoying two wins and a draw from their five matches.
Howe and his side have endured a poor start to the season, with the Cherries suffering from the dreaded second season syndrome.
The Cherries have had a tough run at both ends of the pitch, conceding five goals and scoring only two.
Jack Wilshere's arrival has been dubbed the greatest ever signing for the club, with the Gunners midfielder making the move on loan.
Wilshere's signing is an excellent move for both sides, with Bournemouth proving they can sign high-class players.
This is also a key move for the midfielder, he will be desperate to register invaluable game time and Bournemouth will need him to remain fit.
Bournemouth will be looking to continue their overall record against West Brom. In 5 matches, they have won 2, drawn 1 and lost 2.
Bournemouth are 21/20 with Callum Wilson and Joshua King at 5/1 to open the scoring.
West Brom have endured an inconsistent start this season, in their three games they have registered every result possible.
They won their opening match of the season against Palace, a great victory for the club away from home.
Tony Pulis' side followed that up with a 2-1 defeat at home against Everton, this despite taking the lead through Gareth McCauley.
Their last fixture prior to the international break was a 0-0 draw against Middlesbrough, with the newly promoted side proving more than a match for the Baggies.
Pulis' men have also struggled up front, but they have only conceded two goals, with both of them coming in the second match against Everton.
Early signs this season have suggested that West Brom will struggle again, the lack of transfer activity has reportedly disappointed Pulis.
The club have managed to retain the services of Saido Berahino, with striker Salomon Rondon as well they have an excellent front line.
Nacer Chadli has arrived from Tottenham, this was an excellent signing for a modest fee of just £13 million.
Along with the free signing of Wales hero Hal Robson-Kanu, as well as the former Liverpool favourite Mohammed Sissoko training at the club they have gone in the right direction.
Bournemouth Represent Great Opportunity
West Brom face another challenge in the form of Bournemouth this weekend, these are the types of games that the Baggies will be targeting for maximum points.
The Baggies failed to beat Bournemouth last season, with a 1-1 draw and a 2-1 defeat in their two meetings last season.
Both sides will be targeting goals and a clean sheet, more important will be the win as they both look to climb up the table.
West Brom are 14/5 with Salomon Rondon at 13/2 to open the scoring.
Tip 1 – Zlatan to score first @ 4/1 with a 2-2 draw @ 12/1
Tip 2 - Perez to score first @ 4/1 and Arsenal to win 3-1 @ 12/1
Tip 3 - King to score first @ 5/1 and a 2-2 draw @ 18/1